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Competencies & Equipment

Main competencies

    • Drug design, synthesis, purification & characterisation
    • Conventional and microwave synthetic technologies
    • Combinatorial /Library design
    • Drug discovery from Natural Products
    • Structure-activity relationships
    • Drug stability studies
    • Mass spectrometry
    • Molecular biology, including cloning
    • Site-directed mutagenesis
    • Reporter gene expression studies
    • Genotyping, SNPs and VNTRs identification
    • Mammalian cell culture (class 10,000 clean rooms)
    • Protein-based assays
    • Cellular-based assays including:
    • Morphology
    • Anti-proliferative /cytotoxic
    • Cell cycle, migration
    • Invasion
    • Apoptosis /anoikis
    • Tubule formation & angiogenesis
    • Ex vivo: aortic ring assay of angiogenesis/vasculature
    • In vivo xenograft models for efficacy, necrosis and tumour vasculature shutdown
    • Quartz Crystal Microbalance with Dissipation (QCM-D)
    • Nano-toxicology evaluation
    • Tumour cell-induced platelet aggregation (TCIPA) analysis
    • Exosomes isolation & characterisation
    • Pre-formulation studies
    • Solid state characterisation
    • In vitro aerosol deposition characterisation
    • Pharmaceutical processing methods:
    • Milling
    • Spray drying
    • Freeze drying
    • Compaction
    • Thermal analysis infrared spectroscopy
    • Powder X-ray diffraction
    • Micromeritic properties analysis
    • Nanoparticle characterisation
    • Pharmacokinetic & pharmacodynamic studies
    • Physicochemical characterisation salts, cocrystals, amorphous, polymeric APIs forms
    • Spray drying
    • Translational clinical trials (with ICORG and first-in-man through spinouts companies)
    • Pharmacoeconomics
    • IP disclosure & patent filing

 

Access to Core Facilities:
Class 10,000 cleanrooms for mammalian cell culture
Microarrays, qPCR
advanced microscopy (confocal microscopy, transmission & scanning electron microscopy)
Fluorescence-activated cell sorting (FACS)
NMR, X-Ray, MS
In vivo core

 

The School of Pharmacy and Pharmaceutical Sciences welcomes new partners and collaborators.
Please contact us at:

The School of Pharmacy & Pharmaceutical Sciences,
Panoz Institute,
Trinity College,
Dublin 2.
Ireland.

School Head and Directors:

Prof. Anne Marie Healy, Head of School

Assoc. Prof. John Walsh, Director of Teaching and Learning (Undergraduate)

Assoc. Prof. John Gilmer, Director of Teaching and Learning (Postgraduate)

Assoc. Prof. Helen Sheridan, Director of Research

Mr. Dimitrios Paraskevas, School Administrator

 

 

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Last updated 15 November 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).