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Drug Development

  • Design, chemical synthesis and evaluation of novel molecular structures as potential clinical drugs: for breast cancerand Burkitt’s Lymphoma

  • Azetidinone analogues of Combretastatin A-4 as tubulin targeting agents

  • Selective Estrogen receptor modulators and tubulin-targeting drugs
  • Pro-drug optimisation of our current candidates

  • Synthesis and biochemistry of ER and tubulin antagonists

  • Dual ER/aromatase and tubulin/aromatase targeting products

  • Dual acting HSP 90 / tubulin targeting products
  • Design of Multidrug resistance/P-glycoprotein modulators

  • Natural Product Drug Discovery

  • Anti-cancer lead discovery from Ethno-medicine (Sub-Saharan Africa, India and Pakistan) and evidence-based traditional Chinese medicine

  • Anti-cancer lead discovery from natural sources (Marine, Terrestrial plants, fungi and microorganisms)
    Cross-hybridisation of naturally occurring molecules to form novel anti-cancer scaffolds

Natural Products

Pharmacy Professors Associated with Disease, Drug Mechanisms & Safety    

Boylan, Fabio http://pharmacy.tcd.ie/staff/DESOUZAF
Frankish, Neil http://pharmacy.tcd.ie/staff/NFRNKISH
Gilmer, John http://pharmacy.tcd.ie/staff/GILMERJF
Meegan, Mary http://pharmacy.tcd.ie/staff/MMEEGAN
Quigley, John http://pharmacy.tcd.ie/staff/JQUIGLEY
Sheridan, Helen http://pharmacy.tcd.ie/staff/HSHERIDN
Walsh, John http://pharmacy.tcd.ie/staff/JJWALSH

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Last updated 15 November 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).