PhD Students in the CDT in Transformative Pharmaceutical Technologies in Ireland
Follow this link for the UK-based student profiles.
Monika MyślińskaPhD Student, School of Pharmacy, Trinity College Dublin. Monika is supervised by Prof. Anne Marie Healy. Email: firstname.lastname@example.org
Hi everyone, my name is Monika Myslinska, and I joined the EPSRC Centre for Doctoral Training in Transformative Pharmaceutical Technologies in 2019 as a PhD student from SSPC, Science Foundation Ireland (SFI) Pharmaceutical Research Centre. I have obtained my diploma in Pharmacy from Medical University of Warsaw (2019). Throughout my college years, I did several scientific internships in Poland and abroad – in the University of Nottingham and University of Lincoln. I did a research for my Master thesis in the University of Reims Champagne-Ardenne in France. I still support the activities of the Polish Pharmaceutical Student Association as an alumna. Nowadays, I am pursuing my PhD in pharmaceutical technology in Trinity College Dublin. My research interests entail looking for methods for enhancing bioavailability and solubility of poorly soluble drugs. Currently I am working on amorphous solid dispersions, which I try to obtain mainly by spray-drying or hot melt extrusion. Outside of work, I enjoy hiking, reading a good book or kayaking.
Evangelia TsolakiPhD Student, School of Chemical and Bioprocess Engineering, University College Dublin. Eva is supervised by Dr Steven Ferguson. Email: email@example.com
Hello, my name is Evangelia Tsolaki and I am a PhD Researcher in the School of Chemical and Bioprocess Engineering at University College Dublin, in Ireland. Starting with a BSc. in Pharmacy, I went on to complete a Master’s in Medicinal Chemistry and Drug Development, both in my hometown university, Aristotle University of Thessaloniki, Greece. During Master’s thesis, I focused on patients with Inflammatory Bowel Diseases, due to their susceptibility to various infections. In times of disease resurgence, these patients exhibit high level of colonization by microorganisms, which appears to contribute to the symptoms and the progression of the disease. To address this vicious circle of inflammation and infection, I designed and synthesized novel drug like molecules with dual mode of action; antimicrobial and anti-inflammatory. I am currently working on the development of novel supramolecular complexes that aim to modify the in vivo solubility and permeability characteristics of poorly bioavailable drugs. Poorly soluble drug candidates, with dissolution rate limited oral bioavailability, are increasingly common in small molecule pharmaceutical development. My project aims to address these limitations and elucidate the potential of this novel formulation approach for orally dosed drug delivery.
Khaled El-KassasPhD Student, School of Pharmacy, University College Cork. Khaled is supervised by Prof. Abina Crean Email: firstname.lastname@example.org
Hello, my name is Khaled El-Kassas.After graduating with a BSc in Pharmacy and Pharmaceutical sciences from my hometown University of Alexandria’s faculty of Pharmacy in Egypt, I was accepted for a research internship at University College Cork, Ireland working on the physicochemical characterisation of polysorbate 80 as a multicomponent surfactant; Following which I joined the School of Pharmacy there as a full time student.My current work focuses on the physicochemical process of reconstitution with regards to high concentration protein drug formulations dried using freeze-drying and comparable alternative techniques. I’d like to think that my work involves a bit of everything from physicochemical characterisation and manufacturing process optimization to mathematical modelling and big data statistical analysis. In what (very little) free time I have, I enjoy painting and sketching, and the occasional good book. I am also an avid runner (even though I’m not very good at it) and enjoy a jog every now and then in the ever-lovely Irish countryside. I’m looking forward to the next few years, learning as much as I can from my peers, my supervisors and everyone at the CDT Ádh mór mian liom!
John DowneyPhD Student, School of Pharmacy, University College Cork. John is supervised by Dr Katie Ryan and Prof. Abina Crean Email: email@example.com
Hello, my name is John Downey. I joined the EPSRC-SFI Centre for Doctoral Training in Transformative Pharmaceutical Technologies as a PhD student of the SSPC in 2020. After graduating with a BSc (Hons) in Biochemistry (2019) I completed my MSc (Research) in Chemistry (2020) from University College Cork where I investigated the crystal energy landscape of 22 sulfonamides, expanding known crystal structures of the substance class by 8. I contributed 1 new polymorph and classified all known sulfonamide crystal structures with respect to intermolecular interactions into 7 graph set groups. I also generated 3 novel cocrystals in this investigation. I was then accepted for a research internship at the INFANT Research Centre, Ireland, working on a proteomics project where I analysed the protein profile in cord blood of children with known ASD outcomes. Following which I joined the School of Pharmacy for my PhD in Pharmaceutics. My current project investigates the effect of different material properties on protein/peptide adsorption behaviour and the consequent impact on protein functional behaviour and stability. I am also examining formulation design to mitigate the risk of protein adsorption to manufacturing equipment and packaging materials.
Aswathy BalakrishnanPhD Student, School of Chemical and Bioprocess Engineering, UCD. Aswathy is supervised by Prof. Liz Topp and Dr Steven Ferguson Email: firstname.lastname@example.org
Hello! My name is Aswathy Balakrishnan and I am pursuing my PhD in Chemical and Bioprocess Engineering with the SSPC-CDT programme at University College Dublin (UCD) and National Institute for Bioprocess Research and Training (NIBRT) in Ireland. I have a bachelor’s degree in Chemical Engineering from Vellore Institute of Technology, India, following which I came to Ireland to do my master’s degree in Biopharmaceutical Engineering at UCD. My master’s thesis involved the design of a manufacturing process for the production of a Prevnar 13 Biosimilar vaccine. This included design of the bioprocess along with PIDs, mass and energy balances, HAZOP analysis, safety and environmental assessment, facility design, as well as economic analysis, in order to determine the overall technical and economic feasibility of the proposed process. Currently, my research revolves around solid state Hydrogen Deuterium Exchange Mass Spectrometry (ssHDX-MS). My project aims to use mechanistic modelling to improve stability and contribute towards the rational design of biopharmaceutical drug formulations. I look forward to the coming years, learning and interacting with my supervisors and colleagues at CDT, UCD and NIBRT!
Maria Ferreira MonteiroPhD Student, School of Pharmacy, Trinity College Dublin. Maria is supervised by Prof. Lidia Tajber Email: email@example.com
Hello, my name is Maria Ferreira Monteiro and I am a PhD researcher at Trinity College Dublin. I have a Masters in Pharmaceutical Sciences from the Faculty of Pharmacy of my hometown University of Porto, in Portugal. Throughout my college years, I also did some research on powder flowability at the Department of Pharmaceutical Technology of my faculty, as well as an Erasmus research internship on microspheres in Poland, at the Department of Pharmaceutical Technology of the Medical University of Gdansk. After I graduated, I did a research internship at Trinity’s department of Pharmaceutics, where I am now doing my PhD. I really enjoy doing research and I find pharmaceutical technology fascinating! Currently I am working on the conversion of poorly soluble drugs into multicomponent systems with low melting points as an approach to improve oral formulations. Outside of work, I like reading, baking, playing board games and RPGs, travelling and I have recently started knitting and crocheting.
Andrew FaganPhD Student, School of Pharmacy, University College Cork. Andrew is supervised by Prof. Abina Crean Email: firstname.lastname@example.org
Hello, my name is Andrew Fagan. I am a recent Dublin City University graduate, where I studied a BSc in Chemical and Pharmaceutical Sciences (2021). During my time there I had the opportunity to carry out an industrial placement in Sublimity Therapeutics Dublin, where I worked as a Production Assistant. Additionally, as part of my final year project I carried out research on the applications of nanomaterials in drug delivery, having the privilege to publish a literature review in the area titled “Spiropyran-based Drug Delivery Systems”. Subsequent to finishing my degree, I began my PhD in University College Cork as part of the EPSRC-SFI Centre for Doctoral Training in Transformative Pharmaceutical Technologies.
My research will essentially take a holistic approach to pharmaceutical tablet manufacturing as part of the overall Quality by Design paradigm currently in place in the pharmaceutical industry, attempting to use statistical and mathematical models to predict the in-vivo performance of tablets from their manufacturing data. Although quite model oriented, my work will also involve pharmaceuticals manufacturing & characterization, along with dissolution studies in both compendial and biorelevant media.
Christina Abscal RuizPhD Student, School of Chemical and Bioprocess Engineering University College Dublin. Christina is supervised by Dr. Ioscani Jiménez del Val Email: email@example.com
Hello, my name is Christina Abscal Ruiz. Currently, I am working under the supervision of Ioscani Jimenez del Val. My research revolves around maximising biopharmaceutical α6-sialylation through CHO cell glycoengineering. My work these following years will focus on developing a biological technology capable of incorporating these features into CHO cells, by CRISPR/Cas9 and other synthetic biologic techniques.
Before coming to Dublin, I completed my BSc in Biotechnology at Pablo Olavide University based in Seville. During this time, I was also involved in scientific divulgation associations and organisation of scientific fairs and congresses. After that, in September 2019, I started an internship in the pharmaceutical industry (Hovione Pharmascience) based in Lisbon. During this time, I gained experience in the pharmaceutical field, carried out projects about nasal delivery vaccines.
I started the MSc in Bioenterprise at University of Granada in September 2020. Along this course, I also started a research internship in Drug Crystallization. After that, I developed my final master’s thesis project in a biotechnological company (Domca) focused on the antitumoral and anti-inflammatory properties of natural products in colorectal cancer cells lines. In my free time, I enjoy dancing and listening flamenco, reading, playing theatre, going out with friends and cooking!
Kate TolanPhD Student, School of Pharmacy, Trinity College Dublin. Kate is supervised by Prof. Anne Marie Healy Email: firstname.lastname@example.org
Hello, my name is Kate Tolan. My current project investigates the use of a metabolomics approach to assess the impact of processing technologies on the phytochemical profile and potentially the biological activity of the plant species: Echinacea Purpurea. I am also assessing the potential for the use of different solidification methods to convert natural product extractions to powdered materials. Selected solidified natural product extracts will be progressed further to capsule or tablet presentation. The overall objective of the project is to ascertain suitable processing and formulation approaches that can be employed to harness the potential of natural products.
I graduated with a BSc (Hons) in Chemistry of Pharmaceutical Compounds from University College Cork in 2021. As part of my final year, I was engaged in two research projects. The first was in the field of biochemistry and investigated the overexpression and purification of the Thermotoga Maritima UvrC protein. The second was an organic chemistry project and investigated the spectroscopic data of the novel HIV drugs α-CNPs. These drugs exist as diastereomers and this work identified a carbon-phosphorus coupling constant which tracked the diastereomeric series.
When I’m not in the lab I spend as much time as possible sailing off the beautiful Irish coast!